Oprah with US First Lady Hillary Clinton

Oprah with First Lady Hillary Clinton in 1995 (Photo by POOL/AFP/Getty Images)

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Oprah at the 1998 "People's Choice Awards." (Photo by Getty Images)

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Oprah backstage at The Vagina Monologues, 2001(Photo by Frank Micelotta/ImageDirect)

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Oprah in 2001 (Photo by George De Sota/Newsmakers)

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Oprah in 2001 (Photo by Spencer Platt/Newsmakers)

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Oprah in 2002 (Photo by Mark Mainz/Getty Images)

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Oprah in 2002 (Photo by Mario Tama/Getty Images)

Oprah & Mandela

Oprah Winfrey and former South African President Nelson Mandela in 2002 (Photo credit should read ALEXANDER JOE/AFP/Getty Images)

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Oprah poses backstage with her "Bob Hope Humanitarian Award"during the Emmy Awards in 2002 (Photo by Robert Mora/Getty Images)

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Oprah in 2002
(Photo by Kevin Winter/Getty Images)

Oprah and Gayle

Oprah and Gayle sit beside Vogue editor Anna Wintour at the Vera Wang Spring/Summer 2003 Collection. (Photo by Mark Mainz/Getty Images)

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Oprah attends the People's Choice Awards in 2004 (Photo by Carlo Allegri/Getty Images)

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Oprah makes a surprise appearance on the Tonight Show to celebrate the show's 50th anniversary. (Photo by NBC/Paul Drinkwater via Getty Images.)

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Oprah in 2004 (Photo by Mike Simons/Getty Images)

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Oprah Winfrey and Maria Maria Shriver in 2004 (Photo by Frederick M. Brown/Getty Images)

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Oprah arrives at the premiere of "Their Eyes Were Watching God" in 2005. SHe was a Producer on the film.(Photo by Mark Mainz/Getty Images)

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Oprah attends the Broadway opening of "The Color Purple" at in 2005. (Photo by Getty Images)

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Oprah (Photo by Getty Images)

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Oprah on stage at the ESPY Awards in 2005. (Photo by Getty Images)

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Oprah at the Tony Awards in 2006. (Photo by Peter Kramer/Getty Images)

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Oprah and Tyler Perry arrive at the screening of "Precious" in 2009.

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Oprah with Cicely Tyson in 2009.

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Oprah and Stedman pose for a photo during the Kennedy Center Honors in 2010. (Photo by Kris Connor/Getty Images)

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Oprah with Julia Roberts in 2010. (Photo by Getty Images)

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Oprah taping the Oprah Winfrey Show in Sydney, Australia in 2010. (Photo by Getty Images)

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Oprah with the graduates of The Oprah Winfrey Leadership Academy of 2011. (Photo by Michelly Rall/WireImage)

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Oprah poses in front of the Taj Mahal in 2012. (Photo by STRDEL/AFP/Getty Images)